4-Methoxy 17β-Estradiol ( —— )

产品货号. M28698 CAS No. 26788-23-8

4-Methoxy-17-estradiol 是雌激素代谢物之一，也是 4-羟基雌二醇的甲基化代谢物。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

4-Methoxy 17β-Estradiol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

4-Methoxy-17-estradiol 是雌激素代谢物之一，也是 4-羟基雌二醇的甲基化代谢物。
产品描述

4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.(In Vitro):4-Methoxy-17-estradiol treatment significantly decreased cell growth and increased mitotic index. Elevation of ROS and SOD activity, with a concomitant decrease in the intracellular GSH/GSSG ratio, was also detected in 4-Methoxy-17-estradiol-treated cells. Quantitative comet assay showed increased oxidative DNA damage in the 4-Methoxy-17-estradiol-treated H1355 cells, which could be significantly reduced by the anti-oxidant N-acetylcysteine (NAC).(In Vivo):4-Methoxy-17-estradiol had much weaker estrogenic activity and have similar lipid-modulating effects compared to 4-hydroxyestradiol in ovariectomized female rats.
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

HDAC2| HDAC6
研究领域

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适应症

——

化学信息

CAS Number

26788-23-8
分子量

302.41
分子式

C19H26O3
纯度

>98% (HPLC)
溶解度

——
SMILES

C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1c(cc1)c3c(OC)c1O)[C@H]2O
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Yodita Asfaha, et al. Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells. Bioorg Med Chem. 2020 Jan 1;28(1):115108.

计算器

浓度计算器

摩尔计算器

分子量计算器

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